FIELD: medicine.
SUBSTANCE: invention relates to a method for producing drugs against SARS-CoV-2 based on the green tea component epigallocatechin-3-gallate (EGCG). In a series of experiments, a non-cytotoxic concentration of EGCG was selected, which was then used in experiments with live virus, which showed that EGCG is the most powerful prophylactic agent, its main target is the SARS-CoV-2 surface protein. These data are confirmed by a detailed in vitro and in silico study of EGCG binding to original and mutated viral S proteins.
EFFECT: results obtained indicate that EGCG prepared according to the claims is particularly effective in preventing infection with mutant SARS-CoV-2.
1 cl, 6 dwg
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Author |
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