METHOD FOR DETERMINING THE FUNCTIONAL ACTIVITY OF ANTITHROMBIN III IN BLOOD PLASMA Russian patent published in 2022 - IPC G01N33/86 G01N33/52 G01N33/543 G01N33/49 

FIELD: medicine.

SUBSTANCE: invention relates to the field of medicine. A method is proposed for determining the functional activity of antithrombin III (AT III) in blood plasma, including the interaction of AT III with heparin. The functional activity of antithrombin III in the studied blood plasma is defined as the concentration of heparin that causes 100% inhibition of the contact coagulation pathway. A plasma sample without heparin is used as a control. In parallel, the activity of the contact pathway of coagulation is determined. The norm of the content of AT III is considered to be the concentration of heparin from 0.31 to 0.625 mcg/ml with normal activity of the contact coagulation pathway.

EFFECT: invention provides reduction in cost, simplification of the test in diagnosing hemostasis disorders, multiple increase in the productivity of the study of the functional activity of AT III in comparison with the prototype, as well as rapid adaptation of the method for routine studies in clinical diagnostic laboratories.

1 cl, 4 tbl, 2 ex