FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, in particular to a human cell - a natural killer (NK), genetically modified for the expression of the TRAIL variant, including the D269H/E195R mutation.
EFFECT: invention is effective for the treatment of cancer.
14 cl, 24 dwg, 1 tbl, 10 ex
| Title |
Year |
Author |
Number |
| CELL THERAPY BASED ON IMPROVED NATURAL KILLER CELLS |
2017 |
- O Dvajer, Majkl Imon Piter
- Khu, Dzhinson
|
RU2776890C2 |
| METHODS OF EX VIVO EXPANSION OF NATURAL KILLER CELLS AND THEIR USE |
2019 |
- Shpall, Elizabeth
- Rezvani, Katy
|
RU2814083C2 |
| METHOD OF PRODUCING GENETICALLY MODIFIED LINES OF CELLS OF NATURAL KILLERS WITH KNOCKOUT PD-1 GENE AND HIGH EXPRESSION OF PROTEINS OF FAMILY OF TUMOUR NECROSIS FACTOR FOR IMMUNOTHERAPY OF ONCOLOGICAL DISEASES |
2019 |
|
RU2731293C1 |
| METHODS OF APPLYING OF APO-2L-RECEPTORS AGONISTS AND NK-CELLS ACTIVATORS |
2005 |
- Godovski Pol Dzh.
- Satial Sandzhiv Kh.
|
RU2395294C2 |
| IMPROVED IMMUNE CELLS WITH DOUBLE shRNA AND COMPOSITIONS CONTAINING THEM |
2019 |
- Kim, Chan Hyuk
- Lee, Young-Ho
- Lee, Yujean
- Lee, Hyeongji
- Lee, Sang Hoon
|
RU2793922C2 |
| COMPOSITION AND METHOD FOR CONTROL OF ACTIVITY OF NATURAL KILLER CELLS |
2004 |
- Padk'Er Seren
- Moretta Alessandro
- K'Eza Mariella Della
- Andre Paskal'
- Got'E Loran
- Vagtmann Peter Andreas Nikolaj Reumert
|
RU2376315C2 |
| CHIMERIC ANTIGEN RECEPTORS WITH MUTATED CD28 COSTIMULATION DOMAINS |
2018 |
|
RU2800922C2 |
| COMPOSITIONS AND METHODS FOR INHIBITING T-CELL DEPUTY |
2018 |
- Makall, Kristal
- Linn, Rejchel
- Veber, Evan
- Sotijo, Elena
|
RU2804282C2 |
| ANALYSES AND METHODS OF BIOMARKER APPLICATION |
2006 |
- Vagner Klaus V.
- Ashkenazi Avi Dzh.
|
RU2409817C2 |
| APOPTOTIC Apo2L/TRAIL SENSITIVITY BY TESTING GalNac-T14 EXPRESSION IN CELLS/TISSUES |
2006 |
- Vagner Klaus V.
- Ashkenazi Avi Dzh.
|
RU2416097C2 |
