RAPIDLY DISSOLVING DOSAGE FORM OF FURAZOLIDONE AND METHOD FOR PRODUCTION THEREOF Russian patent published in 2022 - IPC A61K31/345 A61K31/42 A61K47/58 A61K9/16 A61K9/20 A61P31/02 A61P31/04 A61P33/02 

FIELD: pharmaceuticals.

SUBSTANCE: group of inventions relates to medicine, namely, to pharmaceuticals, and pertains to a composition and method for producing rapidly dissolving dosage forms of furazolidone. The rapidly dissolving dosage form of furazolidone in the form of effervescent granulate or a tablet includes furazolidone, polyvinylpyrrolidone (PVP) with a molecular weight of 24,000±23,500, a granulating agent, an effervescent pair of acidic and basic components and a gliding excipient with the following ratio of components, wt.%: furazolidone 0.010 to 1.200; PVP 24,000±23,500 0.001 to 12.000; granulating agent 0.010 to 10.000; main component 0.010 to 76.000; acidic component 0.010 to 76.000; gliding excipient 0.500 to 4.000. The method for producing said rapidly dissolving dosage form of furazolidone includes the stages of obtaining the acidic and basic granulates, powdering said granulates with the gliding excipient, mixing at the ratio required to achieve a pH of 6.0±0.5 while dissolving the dosage form in water, tableting, or packing in sealed packages.

EFFECT: production of a composition of rapidly dissolving effervescent granules and tablets of furazolidone, characterised by increased solubility and high release of furazolidone from the DF, providing for a therapeutically effective concentration of furazolidone in the solution in less than 5 min.

12 cl, 2 dwg, 3 tbl, 8 ex