METHOD OF PRODUCING DICLOFENAC CAPSULES Russian patent published in 2016 - IPC A61K31/196 A61K47/00 A61K9/16 A61K9/48 A61J3/07 A61P29/00 

FIELD: pharmaceutics.

SUBSTANCE: method of producing diclofenac capsules. Mixture of diclofenac and polyethylene glycol with molecular weight 2,000±400 at weight ratio 1:1-1.5 is dissolved in ethanol at weight ratio of mixture and ethanol 1:0.3-0.6 at temperature of 80±5 °C. Obtained solution at weight ratio of 1:1.75-2 is used for granulation of excipients' mixture: kollidone 90F, polyplasdone XL, starch-1500, lactose, microcrystalline cellulose-101, taken at weight ratio (1:1.9-2.0; 4.6-11.7; 11.7-12.0; 36.0-36.1). Magnesium stearate is added to obtained granulate in amount of 0.5-1.5 % and aerosil of grade 300 is also added in an amount of 2.5-7.5 % of granulate weight. Granulate is dosed in solid gelatinous acid-resistant capsules.

EFFECT: method of producing capsules according to the invention allows to improve bioavailability of non-salt form of diclofenac.

1 cl, 3 tbl