METHOD FOR DIAGNOSTICS OF HIGH-GRADE OVARIAN CARCINOMA SENSITIVE TO BRCA-SPECIFIC DRUGS Russian patent published in 2022 - IPC G01N33/574 A61B5/145 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, in particular to oncology and molecular diagnostics. A method for diagnosing high-grade ovarian carcinoma sensitive to BRCA-specific drugs by detecting the BRCAness phenomenon is proposed. Tumor tissues of the ovary and normal tissues - lymphocytes of the patient's peripheral blood are examined. The BRCAness phenomenon is defined as a combination of a quantitative measure of the number of genome segments with a loss of heterozygosity of at least 22 and the presence of at least two of the following three copy number abnormalities compared to normal tissues: an increase in 8q24 copy number with a simultaneous 8p deletion, detection of a 13q deletion and/or the presence of a gap in the long arm chromosome 22 with loss of telomeric region. When the phenomenon of BRCAness is detected in sporadic ovarian carcinomas, a high-grade ovarian carcinoma sensitive to BRCA-specific drugs is diagnosed.

EFFECT: invention provides individualization of systemic therapy for ovarian cancer by improving the accuracy of determining BRCAness.

1 cl, 3 dwg, 3 ex