FIELD: chemistry.
SUBSTANCE: invention relates to the use of compounds of formula (I) for the treatment of respiratory disease in cattle or respiratory disease of domestic pigs, which are associated with the bacterial pathogens Mannheimia haemolytica, Pasteurella multocida, Histophilus somni or Mycoplasma bovis. In formula (I), A is selected from the group consisting of NRA1RA2 and NO2, RA1, RA2 are independently selected from the group consisting of H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, C1-6alkyloxy-C1-C6-alkyl, C1-C6-alkyl substituted with C6-aryl, C1-C6-alkyl substituted with heteroaryl, where heteroaryl is a cyclic aromatic radical containing 5-6 ring atoms, where 1 ring atom is selected from the group consisting of S, O and N; 0, 1 or 2 ring atoms are additional heteroatoms selected from the group consisting of S, O and N, and the remaining ring atoms are C atoms; C1-C6 alkyl substituted with heterocyclyl, wherein heterocyclyl is a 5-6 membered monocyclic non-aromatic ring system consisting of 4-5 C atoms and 1 heteroatom selected from oxygen; or RA1, RA2 together with the atoms to which they are attached may form a saturated or unsaturated heterocyclic ring containing from 3 to 12 ring atoms, where 1 ring atom is N and where 0, 1 or 2 additional ring atoms are selected from the group, including N, S and O; where alkyl, cycloalkyl, aryl, heterocyclyl, heteroaryl or a heterocyclic ring formed by RA1, RA2 together with the N atom to which they are attached are optionally substituted with a substituent selected from the group consisting of C1-6-alkyl, C3-8-cycloalkyl, C1-6 alkyloxy, -NRA3RA4-, -C(=O)-ORA5-, a halogen atom, etc.; RA3, RA4, RA5 are independently selected from the group consisting of H or C1-6 alkyl; L is absent or represents C1-6-alkyl; M is selected from the group consisting of C6-aryl, heteroaryl, where heteroaryl is a cyclic aromatic radical containing 5-6 ring atoms, where 1 ring atom is selected from the group consisting of S, O and N, and the remaining ring atoms are atoms C; C2-4-alkenyl; G is selected from the group consisting of -C≡C- and -C≡C-C≡C-; Y is C6-aryl; X is -C(=O)-; R1 is selected from the group consisting of H, C1-6 alkyl, C(=O)R9, C(=N-OR8)R8; where each alkyl is optionally substituted with a substituent selected from the group consisting of NR6R7, nitro, hydroxy, -SR8, -SO2R8; R6, R7, R8 are independently selected from the group consisting of H or C1-6 alkyl; R9 is C1-6alkyl; R2, R3 are H; q is 0; R4 is -OR8; R5 is H. The invention also relates to a method for treating or preventing a respiratory disease in cattle or domestic pigs that is associated with said bacterial pathogens.
EFFECT: improvement of method for treatment of respiratory disease in cattle or respiratory disease of domestic pigs.
25 cl, 8 dwg, 9 tbl, 11 ex
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