Show metadata Hide metadata

(19)

(11)

2 775 551

(13)

(51)

IPC

C07D487/04(2006-01-01)

A61K31/53(2006-01-01)

A61P31/12(2006-01-01)

(21) (22)

Application

2019144968, 2019-12-30

(24)

Start date

2019-12-30

(22)

Actual filing date

2019-12-30

(45)

Published

2022-07-04

(72)

Inventor

Rusinov Vladimir LeonidovichDrokin Roman AleksandrovichChupakhin Oleg NikolaevichCharushin Valerij NikolaevichSavateev Konstantin ValerevichUlomskij Evgenij NartsissovichZarubaev Vladimir ViktorovichVolobueva Aleksandra SergeevnaLantseva Kristina Sergeevna

(73)

Holder

Federalnoe Gosudarstvennoe Avtonomnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Federalnyj Universitet Imeni Pervogo Prezidenta Rossii B.N. Eltsina"Federalnoe Byudzhetnoe Uchrezhdenie Nauki Nauchno-Issledovatelskij Institut Epidemiologii I Mikrobiologii Im. Pastera" Federalnoj Sluzhby Po Nadzoru V Sfere Zashchity Prav Potrebitelej I Blagopoluchiya Cheloveka

3-NITRO-4-HYDROXY-7-PROPARGYLTHIO-[1,2,4]TRIAZOLO[5,1c][1,2,4]TRIAZINE AND 3-NITRO-4-HYDROXY-7-ETHYLTHIO-[1,2,4]TRIAZOLO[5,1c][1,2,4]TRIAZINE WITH ANTIVIRAL ACTIVITY Russian patent published in 2022 - IPC C07D487/04 A61K31/53 A61P31/12

Abstract RU 2775551 C2

FIELD: organic chemistry.

SUBSTANCE: invention relates to the field of organic chemistry, namely to 3-nitro-4-hydroxy-1,4-dihydro-7-propargylthio-[1,2,4]triazolo[5,1c]-[1,2,4]triazine and 3-nitro-4-hydroxy-1,4-dihydro-7-ethylthio-[1,2,4]triazolo[5,1c][1,2,4]triazine of formulas 4-5.

EFFECT: new heterocyclic compounds are obtained, having an antiviral activity relatively to enteroviruses.

1 cl, 1 tbl, 5 ex

Similar patents RU2775551C2

Title	Year	Author	Number
2-METHYLTHIO-6-NITRO-1,2,4-TRIAZOLO[5,1-C]-1,2,4-TRIAZINE-7(4H)-ONE SODIUM SALT DIHYDRATE POSSESSING ANTIVIRAL ACTIVITY	2005	Chupakhin Oleg Nikolaevich Rusinov Vladimir Leonidovich Ulomskij Evgenij Nartsissovich Charushin Valerij Nikolaevich Petrov Aleksandr Jur'Evich Kiselev Oleg Ivanovich	RU2294936C1
SODIUM SALT OF 2-METHYL-6-FLUORO-1,2,4-TRIAZOLO[5,1-c]-1,2,4-TRIAZIN-7(4H)-ONE DIHYDRATE, HAVING ANTIVIRAL ACTIVITY	2009	Chupakhin Oleg Nikolaevich Rusinov Vladimir Leonidovich Ulomskij Evgenij Nartsissovich Medvedeva Natal'Ja Rozyevna Kiselev Oleg Ivanovich Deeva Ehlla Germanovna Sinjashin Oleg Gerol'Dovich Mamedov Vakhid Abdulla-Ogly	RU2493158C2
5-METHYL-6-NITRO-7-OXO-4,7-DIHYDRO-1,2,4-TRIAZOLO[1,5-ALPHA]PYRIMIDINIDE L-ARGININIUM MONOHYDRATE	2013	Chupakhin Oleg Nikolaevich Charushin Valerij Nikolaevich Rusinov Vladimir Leonidovich Ulomskij Evgenij Nartsissovich Kotovskaja Svetlana Konstantinovna Kiselev Oleg Ivanovich Deeva Ehlla Germanovna Savateev Konstantin Valer'Evich Borisov Stepan Sergeevich	RU2529487C1
INJECTION OR INFUSION SOLUTION OF L-ARGININE SALT OF 5-METHYL-6-NITRO-1,2,4-TRIAZOLO[1,5-a] PYRIMIDIN-7-ONE MONOHYDRATE FOR THERAPY OF INFLUENZA AND OTHER VIRAL INFECTIONS	2014	Kiselev Oleg Ivanovich Chupakhin Oleg Nikolaevich Charushin Valerij Nikolaevich Rusinov Vladimir Leonidovich Deeva Ella Germanovna Ulomskij Evgenij Nartsissovich	RU2586283C1
4-(4'-HYDROXYBUTYL)-6-PHENYL-1,2,4-TRIAZOLO[5,1-c][1,2,4]TRIAZIN-7-ON	2007	Rusinov Vladimir Leonidovich Chupakhin Oleg Nikolaevich Ulomskij Evgenij Nartsissovich Charushin Valerij Nikolaevich Shestakova Tat'Jana Sergeevna Luk'Janova Ljudmila Sergeevna Deev Sergej Leonidovich Kiselev Oleg Ivanovich Deeva Ehleonora Germanovna Rusinova Larisa Ivanovna	RU2345080C2
SODIUM SALT OF 2-METHYLTHIO-6-CYANO-1,2,4-TRIAZOLO[5,1-C]-1,2,4-TRIAZIN-7(4H)-ONE, TRIHYDRATE	2015	Rusinov Vladimir Leonidovich Chupakhin Oleg Nikolaevich Charushin Valerij Nikolaevich Sapozhnikova Irina Mikhajlovna Medvedeva Natalya Rozyevna Ulomskij Evgenij Nartsissovich Kiselev Oleg Ivanovich Deeva Ella Germanovna Konovalova Nadezhda Igorevna Vasin Andrej Vladimirovich	RU2607628C1
6-(2'-AMINO-2'-CARBOXYETHYLTHIO)-2-METHYLTHIO-4-PIVALOYLOXY-METHYL-1,2,4-TRIAZOLO[5,1-c] 1,2,4-TRIAZIN-7(4H)-ONE	2011	Rusinov Vladimir Leonidovich Chupakhin Oleg Nikolaevich Charushin Valerij Nikolaevich Ulomskij Evgenij Nartsissovich Medvedeva Natal'Ja Rozyevna Kiselev Oleg Ivanovich Deeva Ehlla Germanovna	RU2455304C1
CONJUGATES OF 2-METHYLTHIO-6-NITRO-1,2,4-TRIAZOLO[5,1-c]-1,2,4-TRIAZIN-7(4I')-ONE WITH GLUTADIONE AND OTHER PEPTIDES, POSSESSING ANTIVIRAL ACTIVITY	2012	Kiselev Oleg Ivanovich Chupakhin Oleg Nikolaevich Rusinov Vladimir Leonidovich Charushin Valerij Nikolaevich Deeva Ehlla Germanovna	RU2516936C2
SODIUM SALT OF 3-NITRO-4-OXO-1,4-DIHYDROPYRAZOLO[5,1-c]-1,2,4-TRIAZINE-8-CARBOXYLIC ACID, DIHYDRATE	2016	Rusinov Vladimir Leonidovich Chupakhin Oleg Nikolaevich Charushin Valerij Nikolaevich Sapozhnikova Irina Mikhajlovna Bliznik Anastasiya Mikhajlovna Spasov Aleksandr Alekseevich Petrov Vladimir Ivanovich Kuznetsova Valentina Andreevna Kovaleva Anastasiya Igorevna Vasilev Pavel Mikhajlovich Vorfolomeeva Viktoriya Viktorovna	RU2641107C1
2-[5-(4-METHOXY)-3-PHENYL-5,6-DIHYDRO-4H-[1,2,4,5]TETRAZIN-1-YL]-BENZOTHIAZOLES WITH ANTIVIRAL ACTIVITY AGAINST COXSACKIE B3 VIRUSES	2022	Fedorchenko Tatiana Gennadevna Volobueva Aleksandrina Sergeevna Tungusov Vladislav Nikolaevich Zarubaev Vladimir Viktorovich Lipunova Galina Nikolaevna Chupakhin Oleg Nikolaevich	RU2783659C1

RU 2 775 551 C2

Authors

Rusinov Vladimir Leonidovich

Drokin Roman Aleksandrovich

Chupakhin Oleg Nikolaevich

Charushin Valerij Nikolaevich

Savateev Konstantin Valerevich

Ulomskij Evgenij Nartsissovich

Zarubaev Vladimir Viktorovich

Volobueva Aleksandra Sergeevna

Lantseva Kristina Sergeevna

Dates

2022-07-04—Published

2019-12-30—Filed