COMPOSITIONS AND METHODS FOR USING PHORBOL ETHERS FOR TREATMENT OF STROKE Russian patent published in 2022 - IPC A61K36/47 A61K31/222 A61K31/225 A61K31/23 A61P25/28 

FIELD: pharmaceutical industry.

SUBSTANCE: group of inventions relates to the pharmaceutical industry, namely to a composition for the prevention or treatment of one or more consequences of a stroke in a mammal and a method for the prevention or treatment of one or more consequences of a stroke in a mammal. The composition for the prevention or treatment of one or more consequences of a stroke in a mammal includes the effective amount of phorbol ester of the formula I or its pharmaceutically acceptable salt, isomer or enantiomer,

where R₁ and R₂ are selected from a group consisting of hydrogen, hydroxyl, , where an alkyl group contains from 1 to 15 of carbon atoms; , where a lower alkenyl group contains from 1 to 7 carbon atoms; and ; and R₃ is hydrogen and , where the specified phorbol ether of the formula I excludes 12-O-tetradecanoyl-phorbol-13-acetate (TPA), where one or more of side effects of a stroke is paralysis, spatial perception disorder, blurred consciousness, left ignoring syndrome, aphasia, problems with coordination and balancing, nausea, vomiting, cognitive disorder, perception disorder, orientation disorder, homonymous hemianopia, impaired mobility or impulsivity. The method for the prevention or treatment of one or more consequences of a stroke in a mammal includes the administration of the composition containing the effective amount of phorbol ether of the formula I or its pharmaceutically acceptable salt, isomer or enantiomer to the specified mammal.

EFFECT: above-described composition is effective for the prevention or treatment of one or more consequences of a stroke in a mammal, where one or more of side effects of a stroke is paralysis, spatial perception disorder, blurred consciousness, left ignoring syndrome, aphasia, problems with coordination and balancing, nausea, vomiting, cognitive disorder, perception disorder, orientation disorder, homonymous hemianopia, impaired mobility or impulsivity.

13 cl, 1 tbl, 10 ex