PHORBOL ESTER COMPOSITIONS AND METHODS OF USING THEM FOR TREATING OR REDUCING DURATION OF CYTOPENIA Russian patent published in 2020 - IPC A61K31/22 A61K38/19 A61P7/06 

FIELD: medicine.

SUBSTANCE: group of inventions relates to a method of treating cytopenia, comprising administering to a mammal a subject in need thereof an effective amount of phorbol ester of formula II, its pharmaceutically acceptable salt, isomer, enantiomer, solvate or hydrate in combination with a granulocyte colony-stimulating factor (G-CSF) in an effective amount of 150 mcg to 400 mcg. Group of inventions also relates to a method of treating cytopenia, comprising administering to a mammal a subject in need thereof, effective amount of phorbol ester of formula II, its pharmaceutically acceptable salt, isomer, enantiomer, solvate or hydrate in combination with erythropoietin (EPO) in an effective amount, selected from a group comprising amount of 75 IU/kg to 900 IU/kg of EPO, amount of 2,000 to 40,000 EPO units and amount of 40,000 to 60,000 EPO units; compositions for treating cytopenia, containing an effective amount of phorbol ester of formula II, its pharmaceutically acceptable salt, isomer, enantiomer, solvate or hydrate and granulocyte colony-stimulating factor (G-CSF) in an effective amount of 150 mcg to 400 mcg.

EFFECT: group of inventions provides reduced duration of cytopenia.

22 cl, 5 tbl, 6 ex, 2 dwg