USE OF CYTOTOXIC AGENTS BASED ON SUBSTITUTED POTASSIUM 1-AMINO-1,6-DIOXO-2-CYANO-1-ETHOXY-6-R1-4-[((3-ETHOXYCARBONYL)-4,5,6,7-TETRAHYDROBENZO[b]THIOPHEN-2-yl)AMINO]HEXA-2,4-DIEN-3-OLATES IN TREATMENT OF LUNG MELANOMA Russian patent published in 2023 - IPC A61K31/381 A61P35/00 C07D333/66 

Abstract RU 2808533 C1

FIELD: organic; medicinal chemistry.

SUBSTANCE: invention relates to the use of substituted potassium 1-amino-1,6-dioxo-2-cyano-1-ethoxy-6-R1-4-[((3-ethoxycarbonyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)amino]hexa-2,4-dien-3-olates of general formula 1 a-c, where R1 =Ph (a), 4-MeC 6 H 5 (b), 4-MeOC 6 H 5 (c), as anticancer agents in the treatment of lung melanoma.

EFFECT: treatment of lung melanoma provided by an anticancer low-toxic agent of the specified structure 1 a-c.

1 cl, 1 tbl, 5 ex

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RU 2 808 533 C1

Authors

Shipilovskikh Sergei Aleksandrovich

Timin Aleksandr Sergeevich

Dates

2023-11-29Published

2023-04-13Filed