FIELD: organic; medicinal chemistry.
SUBSTANCE: invention relates to the use of substituted potassium 1-amino-1,6-dioxo-2-cyano-1-ethoxy-6-R1-4-[((3-ethoxycarbonyl)-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)amino]hexa-2,4-dien-3-olates of general formula 1 a-c, where R1 =Ph (a), 4-MeC 6 H 5 (b), 4-MeOC 6 H 5 (c), as anticancer agents in the treatment of lung melanoma.
EFFECT: treatment of lung melanoma provided by an anticancer low-toxic agent of the specified structure 1 a-c.
1 cl, 1 tbl, 5 ex
| Title |
Year |
Author |
Number |
| APPLICATION OF AN ANALGESIC AGENT BASED ON POTASSIUM 1,6-DIOXO-6-(4-CHLOROPHENYL)-2-CYANO-1-ETHOXY-4-[((3-ETHOXYCARBONYL)-4,5,6,7-TETRAHYDROBENZO[b]THIOPHENE-2-YL)AMINO]HEXA-2,4-DIENE-3-OLATE |
2021 |
- Shipilovskikh Sergej Aleksandrovich
- Rubtsov Aleksandr Evgenevich
- Makhmudov Ramiz Ragibovich
- Shipilovskikh Darya Aleksandrovna
|
RU2776070C1 |
| 1-AMINO-1,6-DIOXO-6-(4-CHLOROPHENYL)-2-CYANO-4-(3-CYANO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHEN-2-YL)AMINO)HEXA -2,4-DIEN-3-OLATE POTASSIUM WITH ANTI-INFLAMMATORY ACTIVITY |
2022 |
- Shipilovskikh Sergei Aleksandrovich
- Makhmudov Ramiz Ragibovich
- Lipin Dmitrii Vladimirovich
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|
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2021 |
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|
RU2776068C1 |
| 2-CYANO-4-[1,6-DIOXO-6-(4-METHYLPHENYL)-1-ETOXY-4-(3-CYANO-4,5,6,7-TETRAHYDROBENZO[b]THIOPHEN-2-IL)AMINO]HEXA-2,4-DIEN-3-OLATE POTASSIUM WITH ANALGESIC ACTIVITY |
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|
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2021 |
- Shipilovskikh Sergej Aleksandrovich
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|
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|
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2023 |
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|
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| POTASSIUM 2-(4-BROMOPHENYL)-6-OXO-4-(PHENYLIMINO)-1,6-CYANO-1-((4-CYANO-3-TETRAHYDROBENZO[b]THIOPHEN-4,5,6,7-YL)AMINO)-2-ETOXYHEXA-2,4-DIENE-3-OLATE WITH ANALGESIC ACTIVITY |
2023 |
- Shipilovskikh Sergei Aleksandrovich
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- Lipin Dmitrii Vladimirovich
|
RU2810078C1 |
| ETHYL ETHER OF 2-(((Z)-AMINO((Z)-2,4-DIOXO-5-(2-OXO-2-PHENYLETHYLIDENE)PIRROLIDINE-3-YLIDEN)METHYL)AMINO)-4,5,6,7-TETRAHYDROBENZO[b]THIOPHENCARBOXYLIC ACID WITH ANALGETIC ACTIVITY |
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- Vasileva Anastasiya Yurevna
|
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| APPLICATION OF AN ANALGESIC AGENT BASED ON ETHYL ETHERS OF 2-[(5-HYDROXY-5-PHENYL-2-OXO-1-R-2,5-DIHYDRO-1H-PYRROLE-3-YL)AMINO]-4,5,6,7-TETRAHYDROBENZO[b]THIOPHENE-3-CARBOXYLIC ACID |
2021 |
- Shipilovskikh Sergej Aleksandrovich
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|
RU2776072C1 |
