2-CYANO-4-[1,6-DIOXO-6-(4-METHYLPHENYL)-1-ETOXY-4-(3-CYANO-4,5,6,7-TETRAHYDROBENZO[b]THIOPHEN-2-IL)AMINO]HEXA-2,4-DIEN-3-OLATE POTASSIUM WITH ANALGESIC ACTIVITY Russian patent published in 2023 - IPC C07D333/66 A61K31/381 A61P29/00 

Abstract RU 2798429 C1

FIELD: chemistry.

SUBSTANCE: invention relates to 2-cyano-4-[1,6-dioxo-6-(4-methylphenyl)-1-ethoxy-4-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophene-2-yl)amino]hexa-2,4-dien-3-olate potassium, which has analgesic activity.

EFFECT: obtaining new compound with a high yield, with a pronounced analgesic activity, as well as low toxicity.

1 cl, 1 tbl, 3 ex

Similar patents RU2798429C1

Title Year Author Number
POTASSIUM 2-(4-BROMOPHENYL)-6-OXO-4-(PHENYLIMINO)-1,6-CYANO-1-((4-CYANO-3-TETRAHYDROBENZO[b]THIOPHEN-4,5,6,7-YL)AMINO)-2-ETOXYHEXA-2,4-DIENE-3-OLATE WITH ANALGESIC ACTIVITY 2023
  • Shipilovskikh Sergei Aleksandrovich
  • Makhmudov Ramiz Ragibovich
  • Lipin Dmitrii Vladimirovich
RU2810078C1
APPLICATION OF AN ANALGESIC AGENT BASED ON POTASSIUM 1,6-DIOXO-6-(4-CHLOROPHENYL)-2-CYANO-1-ETHOXY-4-[((3-ETHOXYCARBONYL)-4,5,6,7-TETRAHYDROBENZO[b]THIOPHENE-2-YL)AMINO]HEXA-2,4-DIENE-3-OLATE 2021
  • Shipilovskikh Sergej Aleksandrovich
  • Rubtsov Aleksandr Evgenevich
  • Makhmudov Ramiz Ragibovich
  • Shipilovskikh Darya Aleksandrovna
RU2776070C1
1-AMINO-1,6-DIOXO-6-(4-CHLOROPHENYL)-2-CYANO-4-(3-CYANO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHEN-2-YL)AMINO)HEXA -2,4-DIEN-3-OLATE POTASSIUM WITH ANTI-INFLAMMATORY ACTIVITY 2022
  • Shipilovskikh Sergei Aleksandrovich
  • Makhmudov Ramiz Ragibovich
  • Lipin Dmitrii Vladimirovich
  • Kozlov Danil Anatolevich
RU2798468C1
OBTAINING 6-(4-BROMOPHENYL)-6-OXO-1-(PHENYLIMINO)-2-CYANO-4-((3-CYANO-4,5,6,7-TETRAHYDROBENZO[b]THIOPHEN-2-YL)AMINO)-1-ETOXYHEXA-2,4-DIENE-3-OLATE POTASSIUM WITH ANALGESIC ACTIVITY 2023
  • Shipilovskikh Sergei Aleksandrovich
  • Makhmudov Ramiz Ragibovich
  • Lipin Dmitrii Vladimirovich
  • Silaichev Pavel Sergeevich
RU2808997C1
USE OF CYTOTOXIC AGENTS BASED ON SUBSTITUTED POTASSIUM 1-AMINO-1,6-DIOXO-2-CYANO-1-ETHOXY-6-R1-4-[((3-ETHOXYCARBONYL)-4,5,6,7-TETRAHYDROBENZO[b]THIOPHEN-2-yl)AMINO]HEXA-2,4-DIEN-3-OLATES IN TREATMENT OF LUNG MELANOMA 2023
  • Shipilovskikh Sergei Aleksandrovich
  • Timin Aleksandr Sergeevich
RU2808533C1
2-((3-CYANO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHEN-2-YL)AMINO)-4-(4-METHOXYPHENYL)-4-OXOBUTT-2-ENOIC ACID BENZYL ETHER WITH ANALGIC ACTIVITY 2022
  • Shipilovskikh Sergei Aleksandrovich
  • Makhmudov Ramiz Ragibovich
  • Gorbunova Irina Aleksandrovna
  • Sharaveva Iuliia Olegovna
RU2798424C1
ETHYL ETHER 2-AMINO-(3-CYANO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHEN-2-YL)-5-(2-(4-ETHYLPHENYL)-2-OXOETHYLIDENE)-4-OXO- 4,5-DIHYDRO-1H-PYRROL-3-CARBOXYLIC ACID WITH ANALGESIC ACTIVITY 2023
  • Shipilovskikh Sergei Aleksandrovich
  • Makhmudov Ramiz Ragibovich
  • Lipin Dmitrii Vladimirovich
  • Parkhoma Kseniia Iurevna
RU2810070C1
4-(4-METHOXYPHENYL)-4-OXO-N-PHENYL-2-((3-CYANO-4,5,6,7-TETRAHYDROBENZO[b]THIOPHEN-2-YL)AMINO)BUT-2-ENAMIDE WITH ANALGESIC ACTIVITY 2023
  • Shipilovskikh Sergei Aleksandrovich
  • Makhmudov Ramiz Ragibovich
  • Gorbunova Irina Aleksandrovna
RU2810072C1
4-OXO-N-(FURAN-2-YLMETHYL)-4-(4-CHLOROPHENYL)-2-((3-CYANO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHEN-2-YL)AMINO)BUT-2-ENAMIDE WITH ANALGESIC ACTIVITY 2022
  • Shipilovskikh Sergei Aleksandrovich
  • Makhmudov Ramiz Ragibovich
  • Gorbunova Irina Aleksandrovna
  • Okoneshnikova Elizaveta Aleksandrovna
RU2798425C1
APPLICATION OF 4-(4-METHOXYPHENYL)-4-OXO-2-[(3-(CYANO)-4,5,6,7-TETRAHYDROBENZO[b]THIOPHEN-2-yl)AMINO]BUT-2-ENOIC ACID AS AN ANALGESIC DRUG 2022
  • Shipilovskikh Sergei Aleksandrovich
  • Makhmudov Ramiz Ragibovich
  • Rubtsov Aleksandr Evgenevich
RU2785784C1

RU 2 798 429 C1

Authors

Shipilovskikh Sergei Aleksandrovich

Makhmudov Ramiz Ragibovich

Lipin Dmitrii Vladimirovich

Kozlov Danil Anatolevich

Dates

2023-06-22Published

2022-07-01Filed