FIELD: biotechnology.
SUBSTANCE: there are presented: a glycosylated polypeptide containing an amino acid sequence, having at least 90 % identity to at least a fragment of von Willebrand factor (vWF), as well as use thereof to reduce the immune response to a second polypeptide, in particular a therapeutic protein, composition for treating or preventing a bleeding disorder in a patient, comprising a first and a second polypeptide in an effective amount, an isolated polynucleotide encoding a glycosylated polypeptide, a vector for producing a glycosylated polypeptide and a host cell.
EFFECT: novel molecule comprising an amino acid sequence having at least 90 % identity to at least a human von Willebrand factor (vWF) fragment, allows using it for effective treatment and prevention of blood clotting disorders in patient.
24 cl, 17 dwg, 13 ex
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