METHOD FOR INTRODUCTION OF PALIPERIDONE PALMITATE SUSPENSION FOR INJECTIONS WITH PROLONGED RELEASE Russian patent published in 2022 - IPC A61K31/519 A61P25/18 

Abstract RU 2777552 C2

FIELD: medicine; psychiatry.

SUBSTANCE: invention relates to medicine, namely to psychiatry; it can be used for the treatment of schizophrenia. A method includes the intramuscular injection to a patient of the first loading dose from 200 mg to 300 mg of paliperidone in the form of paliperidone palmitate on the first day of treatment. Starting from 29th day ± 7 days from the injection of the first loading dose, the patient is intramuscularly injected with the first monthly supporting dose in the range from 50 mg to 150 mg of paliperidone in the form of paliperidone palmitate. Each dose of paliperidone palmitate is included in a composition of an aqueous suspension.

EFFECT: use of the invention allows for faster release of a drug and smaller fluctuations of its concentration during the first two months.

11 cl, 18 dwg, 11 tbl, 4 ex

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RU 2 777 552 C2

Authors

Li, Yusin

Sha, Chuntsze

Chzhao, Fentszyuan

Tu, Chanbin

Sun, Kaosyan

Lyu, Vankhuej

Sun, Lifan

Men, In

Dates

2022-08-08Published

2018-10-26Filed