LIPOSOME-CONTAINING COMPOSITION Russian patent published in 2022 - IPC A61K31/7024 A61K9/127 A61K47/24 A61K47/28 

FIELD: medicine.

SUBSTANCE: group of inventions relates to the field of medicine and pharmaceuticals. The first invention of the group is a liposome-containing composition for suppressing the binding of lipopolysaccharides to TLR4, wherein the liposomes contain 0.7 to 3.0% mol. of eritoran or a pharmaceutically acceptable salt thereof, 0.5 to 3.0% mol. of a pegylated phospholipid, and 0 to 10% mol. of sterol as calculated for the liposome, wherein the pegylated phospholipid constitutes 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000]. The second invention of the group is a method for producing said composition, including producing a solution containing 0.7 to 3.0% mol. of eritoran or a pharmaceutically acceptable salt thereof, 0.5 to 3.0% mol. of a pegylated phospholipid, and a solvent as calculated for all components of the liposomes subject to use; evaporating the solvent from the solution forming a thin film; dispersing the thin film in a buffer solution forming a liquid dispersion, and extruding the liquid dispersion through a filter forming a composition.

EFFECT: group of inventions provides compositions with increased activity in terms of suppression of IL-6 and/or TNF-ɑ production.

20 cl, 5 dwg, 11 tbl, 26 ex