FIELD: biotechnology.
SUBSTANCE: invention relates to a crystal form of 4-fluor-3-(2-oxo-2-{2-[4-(trifluoromethyl)phenyl]-6,7-dihydro-5H-imidazo[1,2-a][1,4]diazepine-8(9H)-yl}ethyl)-1,3-benzoxazole-2(3H)-one, having characteristic peaks at angles 2θ(°) 7.0, 9.4, 12.3, 15.8, 17.4, 18.9, 19.6, 21.3, 23.8, 25.0.
EFFECT: 4-fluor-3-(2-oxo-2-{2-[4-(trifluoromethyl)phenyl]-6,7-dihydro-5H-imidazo[1,2-a][1,4]diazepine-8(9H)-yl}ethyl)-1,3-benzoxazole-2(3H)-one in a crystal form, having positive allosteric modulating effect (PAM effect) on dopamine D1 receptor.
1 cl, 12 tbl, 14 ex
| Title | Year | Author | Number |
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