6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZINONE DERIVATIVE AND ITS APPLICATION IN MEDICINE Russian patent published in 2023 - IPC C07D519/00 C07D487/04 A61K31/4985 A61P25/00 A61P25/04 A61P25/18 A61P25/20 A61P25/22 A61P25/30 A61P3/00 

FIELD: pharmaceuticals.

SUBSTANCE: in formula (1): R¹ and R² independently represent a hydrogen atom, a halogen atom, or C_1-4 alkyl, where each alkyl is independent and may be optionally substituted with 1 to 5 identical or different substituents selected from the group consisting of a halogen atom, a hydroxyl group, and C_1-4 alkoxy, or alternatively R¹ and R² together with the carbon atom to which they are attached form a cyclopropane ring or cyclobutane ring; ring A represents a C_6-10 aromatic carbocyclyl group, a 4-10 membered saturated heterocyclyl group, or a 5-10 membered aromatic heterocyclyl group, wherein the heterocyclyl group includes the same or different heteroatoms selected from the group consisting of an oxygen atom, a nitrogen atom, and a sulfur atom; R³ and R⁴ independently represent a hydrogen atom, a halogen atom, C_1-6 alkyl, C_1-4 alkoxy or C_2-4 alkenyl, where alkyl and alkoxy are independent and they can be optionally substituted from 1 to 5 the same or different halogen atoms; R⁵ and R⁶ independently represent a hydrogen atom, a halogen atom, C_1-6 alkyl, C_1-6 alkoxy, where each alkyl and alkoxy are independent and may be optionally substituted with 1 to 5 identical or different halogen atoms, C_{3 -6} saturated carbocyclyl group or -NR^a R^b ; R^a and R^b independently, and when multiple NR^a R^b are present, each of the R^a groups or R^b groups independently represents a hydrogen atom, C_1-4 alkyl, where each alkyl is independent and may be optionally substituted from 1 up to 5 identical or different substituents selected from the group consisting of a halogen atom, or, alternatively, R^a and R^b together with the nitrogen atom to which they are attached, can form a 4-6-membered nitrogen-containing saturated heterocyclyl group, where the nitrogen-containing saturated heterocyclyl group may be optionally substituted with 1 to 5 identical or different halogen atoms; Xrepresents a nitrogen atom or-CR^e -; and R^e represents a hydrogen atom, a halogen atom, or C_1-4 alkyl optionally substituted with 1 to 5 identical or different halogen atoms. Also, a pharmaceutical composition, a therapeutic and/or prophylactic agent, the use of a compound of formula (1), a method for treating and/or preventing a disease, and methods for preparing a compound of formula are provided (1a).

EFFECT: proposed compound can be used to prevent and/or as a drug for the treatment of a disease in which the group II mGlu receptor is involved.

36 cl, 3 dwg, 3 tbl, 38 ex