FIELD: organic chemistry.
SUBSTANCE: invention relates to the field of organic chemistry, namely to a heterocyclic compound of the formula (I), where R is selected from a group consisting of 3-chlor-4-fluorphenyl, 2-fluor-4-iodophenyl, 4-chlor3-(trifluoromethyl)phenyl, 3-(1,1-dimethylethyl)-1-methyl-1H-pyrazole-5-yl, 3-(trifluoromethoxy)phenyl. The invention also relates to a pharmaceutical composition based on the compound of the formula (I) and a method for the treatment, relief and/or prevention of a skin side reaction to EGFR inhibitors, PI3K inhibitors, MEK inhibitors or combinations thereof.
EFFECT: relief of skin side reactions related to the administration of EGFR inhibitors, PI3K inhibitors, MEK inhibitors or combinations thereof by Braf inhibitor with the formula (I).
(I)
24 cl, 28 dwg, 7 tbl, 22 ex
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