NEW SPIROBICYCLIC ANALOGUES Russian patent published in 2023 - IPC C07H19/14 C07D307/94 C07D317/44 C07D471/04 A61K31/505 A61K31/52 A61P35/00 

FIELD: pharmaceutics.

SUBSTANCE: present invention relates to a new spirobicyclic analogue of the formula (I)

or to its pharmaceutically acceptable salt of attachment, which are suitable as PRMT5 inhibitors. In addition, the present invention relates to pharmaceutical compositions containing the specified compounds as an active ingredient, as well as to intermediate compounds for the production of these compounds. In the formula (I), R¹ and R² are hydrogen or -C(=O)-C_1-4alkyl; R^3a is halogen, -NR^7aR^7b; Q¹ is CR^6a; Q² is N or CR^6b; X, R^7a, R^7b, R^4a, R^6a, and R^6b are hydrogen; Y is -O- or -CH₂-; L is -CH₂-, -O-CH₂-, -CH₂-O-, or -O-; R⁵ is Ar or Het; and, in case if L is -O- or -O-CH₂-, R⁵ can also be hydrogen; Ar is phenyl; Het is a monocyclic or bicyclic ring system selected from a group consisting of (a-1), (a-2), (a-3), (a-4), (a-5), (a-6), and (a-7),

where the specified monocyclic or bicyclic aromatic ring system is optionally substituted with one or several substitutes, each of which is independently selected from a group consisting of halogen and -NH2.

EFFECT: obtainment of new spirobicyclic analogues.

17 cl, 5 tbl, 4 ex