ANTIBODY BINDING HUMAN IL-4R, ANTIGEN-BINDING FRAGMENT THEREOF, AND MEDICAL APPLICATION THEREOF Russian patent published in 2022 - IPC C07K16/28 A61K39/395 C12N15/13 

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology, in particular, an antibody binding human IL-4R, an antigen-binding fragment thereof, and a medical application thereof. Proposed are a chimeric antibody and a humanised antibody, including a CDR region from an antibody binding human IL-4R and an antigen-binding fragment thereof; a pharmaceutical composition including an antibody binding human IL-4R and an antigen-binding fragment thereof, and an application thereof as a medicinal product treating an allergic disease. Also proposed is an application of the humanised IL-4R-binding antibody in the production of a medicinal product used to treat IL-4R-mediated conditions or diseases.

EFFECT: invention allows for effective treatment of IL-4R mediated diseases.

17 cl, 1 dwg, 12 tbl, 11 ex