FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, in particular, an antibody binding human IL-4R, an antigen-binding fragment thereof, and a medical application thereof. Proposed are a chimeric antibody and a humanised antibody, including a CDR region from an antibody binding human IL-4R and an antigen-binding fragment thereof; a pharmaceutical composition including an antibody binding human IL-4R and an antigen-binding fragment thereof, and an application thereof as a medicinal product treating an allergic disease. Also proposed is an application of the humanised IL-4R-binding antibody in the production of a medicinal product used to treat IL-4R-mediated conditions or diseases.
EFFECT: invention allows for effective treatment of IL-4R mediated diseases.
17 cl, 1 dwg, 12 tbl, 11 ex
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