FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, specifically to recombinant production of monoclonal antibodies to a glucagon receptor (hereinafter – GCGR); it can be used in medicine for reduction in glucose concentration in blood. Monoclonal antibodies to GCGR are proposed, containing certain combinations of a heavy chain variable region and a light chain variable region.
EFFECT: invention provides obtainment of antibodies specifically binding to GCGR and bispecific proteins based on them, also including GLP-1 peptide, effective in the treatment of diabetes.
24 cl, 5 dwg, 22 tbl, 9 ex
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