NEUTRALIZING ANTIBODIES TO INFLUENZA B VIRUS AND THEIR APPLICATION METHODS Russian patent published in 2022 - IPC A61K39/00 A61K39/42 C07K16/10 

FIELD: biotechnology.

SUBSTANCE: group of inventions is described, including an isolated antibody or its antigen-binding fragment, having Fc-section variant, where the antibody or its antigen-binding fragment bind to hemagglutinin (hereinafter – HA) of an influenza B virus and neutralize the influenza B virus in two phylogenetically different lines, and have an increased half-life of serum compared to an antibody with native Fc; isolated nucleic acid encoding the above-mentioned antibody or its antigen-binding fragment; a vector for the production of the above-mentioned isolated antibody or the antigen-binding fragment; a host cell expressing the isolated antibody or the antigen-binding fragment; a method for the production of an antibody or its antigen-binding fragment; and a composition for the treatment of an infection caused by an influenza B virus (options).

EFFECT: inventions expand the arsenal of means binding to HA of an influenza B virus and neutralizing the influenza B virus in two phylogenetically different lines.

24 cl, 8 dwg, 12 tbl, 8 ex