FIELD: biotechnology.
SUBSTANCE: invention relates to isolated neutralizing antibodies specific to extracellular domains of LSR protein and can be used in medicine. Antibodies and a pharmaceutical composition with a neutralizing activity are obtained via immunization of a mammal with LSR protein with the SEQ ID NO: 11, 13, 15-17 or 18 and subsequent isolation.
EFFECT: invention makes it possible to make pharmaceuticals for immunotherapy which are effective for the treatment of diseases associated with a decreased activation of T-cells mediated by LSR protein.
27 cl, 38 dwg, 20 tbl, 50 ex
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