FIELD: bioorganic and medical chemistry.
SUBSTANCE: invention relates to the field of bioorganic and medical chemistry of new biologically active derivatives of betulin, betulinic, ursolic, and oleanolic acids, in particular, the invention relates to conjugates of triterpene acids with (E)-4-(1H-indole-3-ylvinyl)-pyridinium bromide of the formula 1-8, which have shown a significant cytotoxic effect in vitro, at low micromolar concentrations, on human tumor cell lines U937 (monocytic leukemia), K562 (chronic myeloid leukemia), and Jurkat (T-lymphoblastic leukemia).
EFFECT: obtainment of new conjugates for the treatment of cancer.
2 cl, 1 tbl, 8 ex
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