METHOD FOR CREATING A TOXIC MODEL OF OPTIC NERVE ATROPHY Russian patent published in 2022 - IPC G09B23/28 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to ophthalmology, and is intended to create a toxic model of optic nerve atrophy for the purpose of subsequent study of the pathological process, development of methods for diagnosis and treatment. To do this, within 24 hours prior to the introduction of methanol, aminophylline is administered orally to rats per the weight of the experimental animal at a concentration of 10 μg/kg 3 times a day. The last dose of Aminophylline is made 8 hours before the injection of methanol solution. Further, by injection into the retrobulbar space of the rat, a 92% methanol solution diluted with 0.9% sodium chloride solution in a ratio of 1:1 is injected. After the injection of methanol over the next 24 hours, Aminophylline is administered orally based on the weight of the experimental animal at a concentration of 10 μg/kg 3 times a day, with the first administration being carried out 2 hours after the injection.

EFFECT: invention provides reliably produced optic nerve atrophy caused by toxic effect of methanol metabolites on optic nerve fibers.

1 cl, 6 dwg, 1 ex, 1 tbl