FIELD: biotechnology; pharmaceutical industry.
SUBSTANCE: genetic structure is presented, containing polynucleotide encoding SERCA2a protein and polynucleotide encoding CCN5 protein; a recombinant expression vector, a method for the prevention or treatment of heart failure, a pharmaceutical composition, the use of a genetic structure for the prevention or treatment of heart failure, and the use of a recombinant expression vector are also presented.
EFFECT: pharmaceutical composition allows for obtainment of a synergetic therapeutic effect provided by a function of SERCA2a protein, which consists in prevention of the loss of cardiomyocytes and increase in the activity of cardiomyocytes, and a function of CCN5 protein, which consists in suppression of fibrosis of heart cells and tissues.
33 cl, 32 dwg, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF CARDIAC ARRHYTHMIA | 2018 |
|
RU2778806C2 |
| CODON-OPTIMIZED NUCLEIC ACID WHICH ENCODES SMN1 PROTEIN, AND USE THEREOF | 2020 |
|
RU2742837C1 |
| ISOLATED MODIFIED VPI CAPSID PROTEIN OF ADENO-ASSOCIATED VIRUS OF SEROTYPE 9 (AAV9), CAPSID AND VECTOR BASED THEREON | 2021 |
|
RU2825667C2 |
| METHODS FOR TREATMENT OF DANON'S DISEASE AND OTHER AUTOPHAGY DISORDERS | 2017 |
|
RU2777571C2 |
| RECOMBINANT VIRAL VECTORS WITH MODIFIED TROPISM AND WAYS OF THEIR USE FOR TARGETED INTRODUCTION OF GENETIC MATERIAL INTO HUMAN CELLS | 2018 |
|
RU2809246C2 |
| TREATMENT OF COMPLEMENT-MEDIATED DISORDERS | 2017 |
|
RU2768982C2 |
| MODIFIED FACTOR IX, AS WELL AS COMPOSITIONS, METHODS AND OPTIONS FOR THE USE OF GENE TRANSFER INTO CELLS, ORGANS AND TISSUE | 2016 |
|
RU2811445C2 |
| GENOTHERAPY CONSTRUCTIONS FOR TREATMENT OF WILSON'S DISEASE | 2020 |
|
RU2807158C2 |
| RECOMBINANT VIRAL PARTICLES WITH MODIFIED TROPISM AND WAYS OF THEIR USE FOR TARGETED INTRODUCTION OF GENETIC MATERIAL INTO HUMAN CELLS | 2018 |
|
RU2811426C2 |
| OPTIMIZED GENES AND EXPRESSION CASSETTES OF MINI-DYSTROPHIN AND THEIR APPLICATION | 2017 |
|
RU2753194C2 |
