ANTIVIRAL PHARMACEUTICAL COMPOSITION CONTAINING FAVIPIRAVIR AND AMINO ACID HYDRATE AND/OR ITS PHARMACEUTICALLY ACCEPTABLE SALT Russian patent published in 2023 - IPC A61K31/4965 A61K47/18 A61K9/08 A61K9/19 A61P31/12 A61P31/14 

FIELD: pharmaceutical industry.

SUBSTANCE: group of inventions relates to the field of chemical and pharmaceutical industry and medicine and concerns a new pharmaceutical composition of favipiravir, a drug based on it and the use of this composition. A pharmaceutical composition is proposed that exhibits preventive and/or therapeutic antiviral activity, containing therapeutically effective amounts of favipiravir and at least one hydrate of a proteinogenic amino acid and/or its pharmaceutically acceptable salt, where the mass ratio of favipiravir to the hydrate of a proteinogenic amino acid and/or its pharmaceutically acceptable salt is 1.0:0.1-1.0:1.1, respectively. It is also proposed to use the above pharmaceutical composition to obtain a drug for the treatment and/or prevention of viral infections and a drug exhibiting preventive and/or therapeutic antiviral activity, containing the above pharmaceutical composition and at least one pharmaceutically acceptable excipient.

EFFECT: use of favipiravir with hydrates of proteinogenic amino acids or their salts at certain mass ratios ensures high stability of the compositions, as well as a high rate of dissolution of the composition in the form of powder or lyophilizate in a pharmaceutically acceptable solvent.

63 cl, 4 dwg, 3 tbl, 4 ex