METHOD OF PRODUCING NOVEL DERIVATIVES OF FAVIPIRAVIR Russian patent published in 2024 - IPC C07D241/24 A61K31/4965 A61P31/12 

FIELD: chemical-pharmaceutical industry; medicine.

SUBSTANCE: invention relates to a method of producing a salt of favipiravir with amino acids. Method comprises reacting an amino acid selected from a group comprising lysine, ornithine, histidine, hydroxylysine and leucine with favipiravir, provided that in an aqueous solution of an amino acid, heated to 60–70 °C, adding a mixture of favipiravir with dimethylformamide in amount of 5–15% of the volume of the amino acid solution in four portions in a weight ratio of 4:2:1:0.5, with further evaporation of the reaction mixture at reduced pressure at temperature not higher than 50 °C.

EFFECT: obtaining novel antiviral compounds, namely favipiravir salts, which have an improved safety profile, as well as improved physical and chemical, technological and pharmacological properties.

4 cl, 2 dwg, 1 tbl, 4 ex