CYCLIC DI-NUCLEOTIDE COMPOUNDS FOR TREATMENT OF CANCER Russian patent published in 2023 - IPC C07F9/6527 C07F9/6574 C07H19/213 A61K31/04 A61K31/7084 A61P35/00 

FIELD: organic chemistry; pharmaceutics.

SUBSTANCE: group of inventions relates to the field of organic chemistry and pharmaceutics; it is aimed at production of new compounds, which are useful in the treatment of cancer. Compounds of the formula (III) or their pharmaceutically acceptable salts are disclosed, where R_1a is selected from a group consisting of H, -OH, and -F; R_1b is selected from a group consisting of H, -OH, and F, where at least one of R_1a and R_1b is -H; R_4a is selected from a group consisting of -H, -OH, and -F; R_4b is selected from a group consisting of -H, -OH, and -F, where at least one of R_4a and R_4b is -H; P₁ and P₂, each independently, has S or R stereochemical configuration; Z is -O- or -NH-; X_1a and X_2a are the same or different and are independently selected from =O or =S; X_1b and X_2b are the same or different and are independently selected from -OR₅ and -SR₅; where R₅ is selected from H and -CH₂OC(O)OC_1-6alkyl; L₁ in the formula (III) is four, five, or six carbon atoms long; where X₁₀, X₁₁, X₁₂, X₁₃, X₁₄, and X₁₅ are independently selected from a bond, -CH₂-, or -CH-, where -CH₂- or -CH- is unsubstituted or substituted with (i) -OH, (iv) -NH₂, or (v) -D, and, if X₁₀ or X₁₅ is a bond, such a bond is not a double bond or a triple bond; and where any two adjacent members of the group, including X₁₀, X₁₁, X₁₂, X₁₃, X₁₄, and X₁₅, may optionally form, with additional atoms, C₃ cycloalkyl or C₃ heterocycloalkyl, the specified C₃ heterocycloalkyl includes N atom; where B₁ and B₂ are independently selected from structures represented in cl.1. In addition, a pharmaceutical composition for the treatment of cancer, containing pharmaceutically effective amount of the specified compounds, the use of compounds for the production of a pharmaceutical composition, and methods for the treatment of cancer, which provide administration of presented compounds to a patient, are disclosed.

EFFECT: group of inventions provides efficient treatment of cancer.

37 cl, 13 dwg, 14 tbl, 114 ex