PYRAZINE COMPOUNDS AND THEIR USE Russian patent published in 2023 - IPC C07D401/04 C07D401/14 C07D405/14 C07D413/04 C07D413/14 C07D417/14 C07D471/04 C07D519/00 A61K31/136 A61K31/337 A61K31/497 A61P35/00 A61P25/16 A61P9/10 

Abstract RU 2809631 C2

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to new pyrazine compounds of Formula I, where A, B, R1, R2, V, W, X, Y, m, n are defined in the claims and act specifically on adenosine receptors, in particular on A2a. The invention also relates to pharmaceutical compositions containing one or more compounds as an active ingredient, and the use of these compounds in the treatment of diseases associated with adenosine receptors (AR), for example cancer, such as non-small cell lung cancer (NSCLC), renal cell carcinoma (RCC), prostate cancer and breast cancer.

EFFECT: obtaining pyrazine compounds and their use.

47 cl, 4 tbl, 308 ex

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RU 2 809 631 C2

Authors

Qi Changhe

Tsui Honchung

Zeng Qingbei

Yang Zhenfan

Zhang Xiaolin

Dates

2023-12-14Published

2019-08-16Filed