SOLID PARTICLES OF SIMETHICONE AND THEIR DOSED FORM Russian patent published in 2023 - IPC A61K9/50 A61K31/80 A61K47/42 A61P1/00 

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine, namely to new solid particles of simethicone and methods for the production of such particles. A microencapsulated simethicone particle for the treatment of discomfort, stress, fullness of the intestine, and abdominal distention is proposed, containing: simethicone and water-soluble coating, wherein simethicone is at least 50% by wt. of the particle, while water-soluble coating is gelatin, whey protein isolate, or a mixture thereof. A tablet for oral resorption, intended for the treatment of discomfort, stress, fullness of the intestine, and abdominal distention; granules soluble in the oral cavity, intended for the treatment of discomfort, stress, fullness of the intestine, and abdominal distention, are proposed. A method for the production of a microencapsulated simethicone particle is proposed, including stages, at which: (a) a solution for water-soluble coating is formed, (b) simethicone and the solution for water-soluble coating are combined, and an emulsion is formed, and (c) spraying drying of the emulsion is carried out. A dosed form for oral use is proposed, intended for the treatment of discomfort, stress, fullness of the intestine, and abdominal distention.

EFFECT: above-mentioned group of inventions allows for obtainment of a microencapsulated simethicone particle for the treatment of discomfort, stress, fullness of the intestine, and abdominal distention.

14 cl, 9 tbl, 13 ex