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2 790 376

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IPC

A61K31/53(2006-01-01)

A61P31/16(2006-01-01)

C07D253/10(2006-01-01)

(21) (22)

Application

2021139820, 2021-12-28

(24)

Start date

2021-12-28

(22)

Actual filing date

2021-12-28

(45)

Published

2023-02-17

(72)

Inventor

Mochulskaya Nataliya NikolaevnaKotovskaya Svetlana KonstantinovnaRusinov Vladimir LeonidovichCharushin Valerij NikolaevichZarubaev Vladimir ViktorovichVolobueva Aleksandrina Sergeevna

(73)

Holder

Federalnoe Gosudarstvennoe Avtonomnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Federalnyj Universitet Imeni Pervogo Prezidenta Rossii B.N. Eltsina"Federalnoe Byudzhetnoe Uchrezhdenie Nauki Nauchno-Issledovatelskij Institut Epidemiologii I Mikrobiologii Im. Pastera" Federalnoj Sluzhby Po Nadzoru V Sfere Zashchity Prav Potrebitelej I Blagopoluchiya Cheloveka

DIMETHYL 7-METHYL-2-(PYRROLIDINE-1-yl)-4-PHENYLPYRROLO[2,1-ƒ][1,2,4]TRIAZINE-5,6-DICARBOXYLATE AND DIMETHYL 7-METHYL-2-(4-R-PHENYL)-4-(4-R-PHENYL)PYRROLO[2,1-ƒ][1,2,4]TRIAZINE-5,6-DICARBOXYLATES EXHIBITING ANTIVIRAL ACTIVITY Russian patent published in 2023 - IPC A61K31/53 A61P31/16 C07D253/10

Abstract RU 2790376 C1

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to the field of biologically active compounds exhibiting antiviral effect against the strain of influenza virus A/Puerto Rico/8/34 (H1N1) and constituting dimethyl 7-methyl-2-(pyrrolidine-1-yl)-4-phenylpyrrolo[2,1-ƒ][1,2,4]triazine-5,6-dicarboxylate by the formula (7)

and dimethyl 7-methyl-2-(4-R¹-phenyl)-4-(4-R²-phenyl)pyrrolo[2,1-ƒ][1,2,4]triazine-5,6-dicarboxylates by the formula (8) , wherein R¹ is Me and R² is Me; or R¹ is Cl and R² is Me; or R¹ is H and R² is Cl.

EFFECT: creation of new chemical compounds of the azoloazine series — dimethyl 7-methyl-2-(pyrrolidine-1-yl)-4-phenylpyrrolo[2,1-ƒ][1,2,4]triazine-5,6-dicarboxylate by the formula (7) and dimethyl 7-methyl-2-(4-R¹-phenyl)-4-(4-R²-phenyl)pyrrolo[2,1-ƒ][1,2,4]triazine-5,6-dicarboxylates by the formula (8), exhibiting a significant antiviral effect against the strain of influenza virus A/Puerto Rico/8/34 (H1N1).

2 cl, 6 ex, 2 dwg

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RU 2 790 376 C1

Authors

Mochulskaya Nataliya Nikolaevna

Kotovskaya Svetlana Konstantinovna

Rusinov Vladimir Leonidovich

Charushin Valerij Nikolaevich

Zarubaev Vladimir Viktorovich

Volobueva Aleksandrina Sergeevna

Dates

2023-02-17—Published

2021-12-28—Filed