FIELD: pharmaceuticals.
SUBSTANCE: invention relates to the field of biologically active compounds exhibiting antiviral effect against the strain of influenza virus A/Puerto Rico/8/34 (H1N1) and constituting dimethyl 7-methyl-2-(pyrrolidine-1-yl)-4-phenylpyrrolo[2,1-ƒ][1,2,4]triazine-5,6-dicarboxylate by the formula (7)
and dimethyl 7-methyl-2-(4-R1-phenyl)-4-(4-R2-phenyl)pyrrolo[2,1-ƒ][1,2,4]triazine-5,6-dicarboxylates by the formula (8) , wherein R1 is Me and R2 is Me; or R1 is Cl and R2 is Me; or R1 is H and R2 is Cl.
EFFECT: creation of new chemical compounds of the azoloazine series — dimethyl 7-methyl-2-(pyrrolidine-1-yl)-4-phenylpyrrolo[2,1-ƒ][1,2,4]triazine-5,6-dicarboxylate by the formula (7) and dimethyl 7-methyl-2-(4-R1-phenyl)-4-(4-R2-phenyl)pyrrolo[2,1-ƒ][1,2,4]triazine-5,6-dicarboxylates by the formula (8), exhibiting a significant antiviral effect against the strain of influenza virus A/Puerto Rico/8/34 (H1N1).
2 cl, 6 ex, 2 dwg
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Authors
Dates
2023-02-17—Published
2021-12-28—Filed