FIELD: chemistry.
SUBSTANCE: invention relates to organic chemistry, specifically to (Z)-7-benzylidene-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine derivatives of formula 1a-d and 2a-c, where R is hydrogen (a), ethyl (b), n-propyl (c) and methyl (d) groups.
Invention also relates to a method of producing compounds of formulas 1a-d and 2a-c.
EFFECT: obtaining novel derivatives of (Z)-7-benzylidene-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine (1, 2), exhibiting activity against influenza A virus, and a method for production thereof is developed, based on reaction of 3-phenyl-2-propinal and 5-substituted 4-amino-4H-1,2,4-triazole-3-thiols.
4 cl, 1 tbl, 8 ex
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