DERIVATIVES OF 1,2,4-TRIAZINE-4-AMINE Russian patent published in 2017 - IPC C07D401/04 A61K31/53 A61P1/16 A61P9/04 A61P13/12 A61P25/06 A61P25/28 

FIELD: pharmacology.

SUBSTANCE: compounds of Iyd formula possess an inhibitory activity against A₁ receptor or A_2a receptor. In formula Iyd B represents "CyBB". "CyBB" represents phenyl optionally having one or more substituents R4c. R4b, R4b' and R4c are, in each case independently, a halogen atom. CN. C1-8 alkyl, which optionally bears one or more substituents selected from halogen atoms, OR5a; C3-8 cycloalkyl; Heta; OR8; N (R9f) (R9g); =O; rr2 is 0-1; and ss tt are, in each case independently, 0 or 1, provided that ss and tt can not simultaneously be equal to 0. L1 and L2 are both single bonds; R8 represents, in each case independently, C1-8 alkyl, which optionally bears one or more substituents selected from halogen atoms. Heta represents, independently in each case, 3-6-membered fully saturated heterocyclic ring which contains one or two heteroatoms selected from O and N. R5a, R9f, R9g are H in each case independently; C1-10 alkyl. The invention also relates to individual compounds, to use of a compound, a pharmaceutical composition and a process for preparing a compound of Iyd formula.

EFFECT: new compounds with an inhibitory activity against A₁ receptor or A_2a receptor.

12 cl, 7 ex