MONOCLONAL ANTIBODY SPECIFICALLY BINDING TO THE THIOREDOXIN-1 EPITOPE, ITS PREPARATION AND APPLICATION Russian patent published in 2023 - IPC C07K16/18 C12N15/13 C12N15/63 G01N33/543 G01N33/574 A61K39/395 C12P21/08 

Abstract RU 2790687 C2

FIELD: immunology.

SUBSTANCE: group of inventions relates to immunology. A monoclonal antibody specifically binding to thioredoxin-1 (Trx1), or its antigen-binding fragment, including a variable region of the light chain containing CDR1 with SEQ ID NO:1, CDR2 with SEQ ID NO:2, CDR3 with SEQ ID NO:3, and a variable heavy chain region containing CDR1 with SEQ ID NO:4, CDR2 with SEQ ID NO:5, CDR3 with SEQ ID NO:6. Nucleic acid molecules encoding light and heavy chains of a monoclonal antibody or its antigen-binding fragment, a recombinant expression vector, a host cell for obtaining a monoclonal antibody or its antigen-binding fragment, a set and methods for the diagnosis of breast cancer are also proposed.

EFFECT: monoclonal antibody has excellent binding affinity with thioredoxin-1, has high sensitivity and specificity, which significantly improves the accuracy and reliability of breast cancer diagnosis.

25 cl, 22 dwg, 25 tbl, 17 ex

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RU 2 790 687 C2

Authors

Suh Kyong Hoon

Kim Dae Joong

Kim Young

Kim Mi Kyung

Jung Jong Hwan

Lee Ki Se

Dates

2023-02-28Published

2018-10-12Filed