FIELD: biotechnology.
SUBSTANCE: epitope of the thioredoxin-1 (Trx1) antigen, a nucleic acid molecule encoding the epitope, a recombinant expression vector, and a host cell for obtaining the epitope are proposed. The epitope region of the human Trx1 antigen consists of an amino acid sequence selected from the group consisting of SEQ ID NO: 34 and 172.
EFFECT: epitope can be used to develop an antibody with improved Trx1 binding affinity, high level of sensitivity and specificity, which is useful for diagnosing breast cancer.
8 cl, 22 dwg, 25 tbl, 17 ex
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