FIELD: biotechnology.
SUBSTANCE: following is proposed: the use of the human thioredoxin-1 (Trx1) antigen epitope consisting of the amino acid sequence of the following SEQ ID NO: 173, for specific binding to a monoclonal antibody or antigen-binding fragment thereof, which comprises a light chain variable region comprising a CDR1 of the following SEQ ID NO: 7, CDR2 with SEQ ID NO: 8 and CDR3 with SEQ ID NO: 9 and a heavy chain variable region comprising CDR1 with SEQ ID NO: 10, CDR2 with SEQ ID NO: 11 and CDR3 with SEQ ID NO: 12.
EFFECT: epitope can be used to develop an antibody with improved Trx1 binding affinity, high level of sensitivity and specificity, which is useful for diagnosing breast cancer.
4 cl, 22 dwg, 25 tbl, 17 ex
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