PHENYL/PYRIDYL-N-PHENYL/PYRIDYL DERIVATIVES FOR THE TREATMENT OF RNA VIRAL INFECTION Russian patent published in 2023 - IPC C07D213/74 C07D213/81 C07D239/10 C07D239/26 C07D401/12 C07D405/12 C07D413/12 A61K31/166 A61K31/44 A61K31/4439 A61K31/444 A61P31/18 

FIELD: pharmacology.

SUBSTANCE: invention relates to a compound of formula (Ic) or any of its pharmaceutically acceptable salts that can be used to treat and/or prevent RNA viral infection caused by an RNA virus belonging to group IV or V of the Baltimore virus classification selected from RSV (respiratory syncytial virus) and chikungunya viruses. In the compound of the formula (Ic), the ring and the ring both represent a phenylene group, or the ring is a pyridylene group, and the ring is a phenylene group; Z” represents –CH₂– or –CO–; R_g is hydrogen and R_h is hydrogen or (C₁–C₄)alkyl; X² represents –CO–NR_k–, where R_k is hydrogen or methyl; –OCH₂–, –CH(OH)–, -NH CO–, –O–, –O–(CH₂)s–O–, where s is 2 or 3, –CO–, –SO₂–, 5-membered heteroaromatic ring containing 1, 2, 3 or 4 heteroatoms, such as triazole, imidazole, tetrazole or oxadiazole, –NH–SO₂–, –NH– or –SO₂–NH–; n is 0, 1, 2 or 3, m and m’ are independently equal to 0, 1 or 2; Y² is hydrogen, halogen, hydroxyl group, (C₁–C₄)alkoxy, etc.; R is (C₁–C₄)alkyl, (C₃-C₆)cycloalkyl, halogen; R’ represents (C₁–C₄)alkyl, optionally interrupted by –SO₂– or –SO–, (C₃-C₆)cycloalkyl or trifluoromethyl group. The invention also relates to the use of a compound of the formula (Ic) for the treatment and/or prevention of the above-mentioned RNA viral infections.

EFFECT: invention also relates to a pharmaceutical composition containing the specified compound and a synthesis method for the production of a compound of the formula (Ic).

9 cl, 5 tbl, 7 ex