ARYL-N-ARYL DERIVATIVES FOR TREATING RNA VIRAL INFECTION Russian patent published in 2024 - IPC C07D213/74 C07D213/81 C07D401/12 A61K31/4406 A61K31/4427 A61K31/496 A61K31/506 A61P31/18 

Abstract RU 2815493 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I) for the treatment and/or prevention of an RNA virus infection caused by an RNA virus belonging to Baltimore group IV or V, selected from Chikungunya viral infection, RSV (respiratory syncytial virus), Dengue and influenza, where ring and ring independently denote a phenylene or pyridylene group, X1 is an ethenylene group, a -NH-CO- group, a -CO-NH- group, Y1 is an aryl group selected from a pyridyl group, a pyrazinyl group or a pyrimidinyl group, X2 is a -O-, -CO-NH-, triazole or -SO2-NH- group, n is 0, 1, 2 or 3, m and m are independently 0 or 1, Y2 is a hydroxyl group, a morpholinyl group, a piperidinyl group, a piperazinyl group optionally substituted with a (C1-C4)alkyl group, or -CR1R2R3 group, where R1, R2 and R3 independently represent a hydrogen atom, a fluorine atom or a (C1-C4) alkyl group, wherein not more than one of R1, R2 and R3 is a hydrogen atom, or R1 and R2 together with the carbon atom carrying them form a (C3-C6) cycloalkyl group, or, alternatively, X2-Y2 is a -C(=O)-NR group with Rd, where Rc and Rd together with a nitrogen atom form a saturated heterocyclic ring, optionally substituted with one or two (C1-C4) alkyl groups, a cyclopentyl group, forming, thus, spirocyclopentyl derivative, or trifluoromethyl group, R and R 'independently represent (C1-C4) alkyl group, (C3-C6) cycloalkyl group, halogen atom, (C1-C5) alkoxy group, provided that when X1 is a -NH-CO- group, Y1 can additionally represent a phenyl group. Invention also relates to a method of producing said compound and a pharmaceutical composition based thereon.

EFFECT: obtaining novel compounds and a pharmaceutical composition based thereon, which can be used in medicine for treating and/or preventing RNA virus infection caused by Chikungunya, RSV, Dengue or influenza viruses.

17 cl, 6 tbl, 8 ex

(I)

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RU 2 815 493 C2

Authors

Scherrer Didier

Tazi Jamal

Mahuteau-Betzer Florence

Najman Romain

Santo Julien

Apolit Cecile

Dates

2024-03-18Published

2019-07-09Filed