METHOD FOR PREDICTION OF SEVERE HAEMORRHAGIC FEVER WITH RENAL SYNDROME AT EARLY STAGES OF DISEASE Russian patent published in 2023 - IPC G01N33/49 G01N33/50 G01N33/573 G01N33/62 

FIELD: immunology and infectology.

SUBSTANCE: invention can be used to predict a severe course of haemorrhagic fever with renal syndrome in the early stages of the disease. In the blood serum of a patient with haemorrhagic fever with renal syndrome is determined in the first week of the disease, as well as the level of urea and alanine aminotransferase (ALT) activity, as well as the percentage of T-cells with CD3+CD8+CD314+ and CD3+CD8+FoxP3+ phenotypes among blood lymphocytes (CD45+). Based on these indicators, the prognosis criterion of severe disease (PCSD HFRS) is calculated according to the formula: PCSD HFRS = 2.015 + 0.072 * [ALT] + 0.516 * [urea] + 0.364 * [CD3+CD8+CD314+] - 0.381 * [CD3+CD8+FoxP3+]. With PCSD HFRS values above 19, the development of a severe course of haemorrhagic fever with renal syndrome is predicted.

EFFECT: method enables early prediction of the risk of developing a severe course of haemorrhagic fever with renal syndrome by determining a wide range of laboratory findings, including immunological parameters.

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