FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, in particular to antibodies, which bind to a human ANGPTL3/8 complex and, thereby, neutralize them; to pharmaceutical compositions containing the mentioned antibodies, to mammalian cells expressing antibodies to ANGPTL3/8 complex, to a method for the production of antibodies to ANGPTL3/8 complex, to a method for reduction in a level of triglycerides, as well as treatment of diseases related to lipid metabolism.
EFFECT: invention allows for an increase in activity of lipoproteinlipase and, thereby, efficient reduction in a level of triglycerides, which can be further used for the treatment of diseases and disorders related to lipid metabolism.
36 cl, 1 dwg, 14 tbl, 5 ex
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