FIELD: biotechnology.
SUBSTANCE: present invention relates to the field of biotechnology, specifically to multi-specific proteins; it can be used in medicine. The invention makes it possible to obtain a molecule of a substance containing more than one immunoglobulin variable domain (ISVD) or nano-bodies and capable of specific binding to both PD1 and CTLA4. The structure of such proteins allows reducing the frequency of binding by natural antibodies in the subject’s body.
EFFECT: invention can be used in the preparation of a drug to increase an immune response in a subject, as well as in the treatment of various malignant tumors and/or the treatment of infectious diseases.
25 cl, 17 dwg, 12 tbl, 10 ex
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