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(19)

(11)

2 509 078

(13)

(51)

IPC

C07D231/56(2006-01-01)

C07D275/04(2006-01-01)

C07D471/04(2006-01-01)

C07D405/12(2006-01-01)

A61K31/416(2006-01-01)

A61K31/437(2006-01-01)

A61K31/428(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2011103454/04, 2009-07-01

(24)

Start date

2009-07-01

(22)

Actual filing date

2009-07-01

(45)

Published

2014-03-10

(72)

Inventor

Khild Robert EhndrjuDzhekson FilipLissikatos DzhozefPrajs StefenSavi Paskal' P'Er

(73)

Holder

Dzhenentek, Ink.

BICYCLIC HETEROCYCLES AS MEK KINASE INHIBITORS Russian patent published in 2014 - IPC C07D231/56 C07D275/04 C07D471/04 C07D405/12 A61K31/416 A61K31/437 A61K31/428 A61P35/00

Abstract RU 2509078 C2

FIELD: biotechnologies.

SUBSTANCE: invention refers to bicyclic heterocycles of formula I and formula II , in which radicals and symbols have values specified in the formula of the invention. These compounds have inhibiting activity in relation to MEK kinase. The invention also refers to a pharmaceutical composition for treatment of hyperproliferation disease or inflammatory disease, to a method for inhibition of abnormal growth of cells or treatment of hyperproliferation disorders and to a treatment method of inflammatory diseases of a mammal. Besides, the invention refers to use of a pharmaceutical composition for preparation of a medicinal agent for treatment of the above diseases of a mammal.

EFFECT: improving compound application efficiency.

19 cl, 29 ex

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RU 2 509 078 C2

Authors

Khild Robert Ehndrju

Dzhekson Filip

Lissikatos Dzhozef

Prajs Stefen

Savi Paskal' P'Er

Dates

2014-03-10—Published

2009-07-01—Filed