FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, specifically to the production of genetically engineered therapeutic drugs, and can be used in medicine to increase the expression level of the target HIF1α gene in humans and animals. A 5057 p.n. GDTT1.8NAS12-HIF1α DNA vector was constructed with the nucleotide sequence of SEQ ID NO: 4 and the general structure shown in FIG. 1D.
EFFECT: invention ensures achievement of a therapeutic effect by introducing a gene therapeutic DNA vector with a target HIF1α gene into cells of an animal and human body characterized by reduced or insufficient expression of the protein encoded by this gene.
3 cl, 15 dwg, 20 ex
