FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, specifically to the production of genetically engineered therapeutic drugs, and can be used in medicine to increase the expression level of the target ANGPT1 gene in humans and animals. A DNA vector GDTT1.8NAS12-ANGPT1 with a size of 4086 bps was constructed with the nucleotide sequence SEQ ID NO: 2 and the general structure shown in dwg. 1B.
EFFECT: invention ensures the achievement of a therapeutic effect by introducing a gene therapy DNA vector with the target ANGPT1 gene into animal and human body cells characterized by reduced or insufficient expression of the protein encoded by this gene.
3 cl, 15 dwg, 20 ex
