FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology, specifically to the production of genetically engineered therapeutic drugs, and can be used in medicine to increase the expression level of the target VEGFA gene in humans and animals. A 3821 bp GDTT1.8NAS12-VEGFA DNA vector was constructed with the nucleotide sequence of SEQ ID NO:3 and the general structure shown in Fig. 1C.
EFFECT: invention provides achievement of a therapeutic effect by introducing a gene therapeutic DNA vector with a target VEGFA gene into cells of an animal and human body characterized by reduced or insufficient expression of the protein encoded by this gene.
3 cl, 15 dwg, 20 ex
