CELL NECROSIS INHIBITOR, METHOD FOR ITS PRODUCTION AND APPLICATION Russian patent published in 2023 - IPC C07D403/12 C07D413/12 C07D471/04 C07D487/04 C07D491/04 C07D495/04 C07D498/04 C07D513/04 A61K31/55 A61K31/553 A61K31/554 A61P1/00 A61P11/00 A61P25/28 

FIELD: organic chemistry.

SUBSTANCE: invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, where X is O or S; the ring M has the structure where ring A is selected from the group consisting of a 5–6 membered heteroaryl containing 1–3 heteroatoms independently selected from nitrogen and oxygen, and a 5-membered heterocyclyl containing 2 nitrogen heteroatoms; ring B is selected from the group consisting of a substituted or unsubstituted 6-membered aryl and a substituted or unsubstituted 5–6 membered heteroaryl containing 1–4 heteroatoms independently selected from nitrogen and oxygen; where "substituted" refers to the substitution of 1 hydrogen atom in the group Deputy selected from C₁-C ₆ alkyl; C is selected from the group consisting of substituted or unsubstituted 6-membered aryl, substituted or unsubstituted 6-membered heteroaryl containing 1 nitrogen heteroatom; where "substituted" refers to the substitution of 1–3 hydrogen atoms in the group Deputy selected from the group consisting of halogen and C₁-C₆ alkyl; L is selected from the group consisting of O, NH, C₁-C ₆ alkylene; R₁ is selected from the group consisting of H and C₁-C₆ alkyl; R₂ is selected from the group consisting of halogen, hydroxyl, oxo, benzyl, C₁-C₆ alkyl, C₁-C₆ haloalkyl, C₁-C₆ alkoxy and C₁-C₆ acyl; and m is 0 or 1; n is 1. The invention also relates to a method for preparing a compound of formula (I), a pharmaceutical composition based on a compound of formula (I), the use of a compound of formula (I), a method for inhibiting RIP1 kinase in a subject, and an intermediate compound of formula (II).

EFFECT: treatment or prevention of diseases mediated by RIP1 kinase provided by the compound of formula (I).

24 cl, 3 dwg, 1 tbl, 29 ex

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