NUCLEOSIDE PHOSPHORYLASES AND NUCLEOSIDASES INHIBITORS Russian patent published in 2008 - IPC C07H19/23 A61K31/7042 A61P31/04 A61P35/00 A61P17/06 A61P19/02 A61P37/06 

FIELD: medicine; pharmacology.

SUBSTANCE: invention refers to new nucleoside analogues characterised as inhibitors of purinephosphoribosiletransferase, purinenucleosidephosphorylase, 5 '-methylthioadenosinephosphorylase, 5 '-methylthioadenosinenucleosidase and/or nucleosidehydrolase and can be applied for treatment of malignant neoplasm, bacterial infections, protozoal infections, T- cell mediated diseases. In formula V is selected of CH₂ and NH, and W is selected of NR¹ and NR²; X is selected of CH₂ and CHOH in R or S - configurations; Y is selected of hydrogen and hydroxy; Z is selected of hydrogen, halogen and hydroxy, SQ and Q where Q is optionally substituted with halogen C₁-C₆alkyl or benzyl group; R¹ is radical of formula ; R² is radical of formula ; A is selected of N, CH; B is selected of OH, NH₂ and halogen; D is selected of NH₂ and hydrogen; E means N; G is selected of CH₂ or G is absent. Invention also refers to based pharmaceutical composition, methods of disease or condition treatment requiring inhibition of purinephosphoribosiletransferase, purinenucleosidephosphorylase, 5 '-methylthioadenosinephosphorylase, 5 '-methylthioadenosinenucleosidase and/or nucleosidehydrolase, and to application of invention compounds for medical product preparation.

EFFECT: products are characterised with increased efficiency.

30 cl, 6 tbl, 19 dwg, 51 ex