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(19)

(11)

2 795 116

(13)

(51)

IPC

A61K31/198(2006-01-01)

A61K39/395(2006-01-01)

A61P43/00(2006-01-01)

(21) (22)

Application

2019128863, 2019-09-13

(24)

Start date

2008-12-26

(22)

Actual filing date

2019-09-13

(45)

Published

2023-04-28

(72)

Inventor

Morichika, ToshiyukiKameoka, DaisukeImaeda, YoshimiMaeda, TerutoshiStauch, Oliver Boris

(73)

Holder

Chugai Seiyaku Kabushiki KaishaF. Hoffmann-La Roche Ag

LIQUID COMPOSITION CONTAINING HIGH CONCENTRATION ANTIBODY Russian patent published in 2023 - IPC A61K31/198 A61K39/395 A61P43/00

Abstract RU 2795116 C2

FIELD: medicinal chemistry.

SUBSTANCE: method for suppressing the deamidation of MRA in an antibody-containing liquid composition. To suppress MRA deamidation in an antibody liquid formulation containing 180 mg/ml of human antibody to IL-6 MRA receptor, 50-300 mM arginine is added to this liquid.

EFFECT: prevention of deamidation during long-term storage.

4 cl, 8 dwg, 4 tbl, 3 ex

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RU 2 795 116 C2

Authors

Morichika, Toshiyuki

Kameoka, Daisuke

Imaeda, Yoshimi

Maeda, Terutoshi

Stauch, Oliver Boris

Dates

2023-04-28—Published

2019-09-13—Filed