SOLUTION PREPARATION CONTAINING STABILIZED ANTIBODIES Russian patent published in 2018 - IPC A61K39/395 A61K31/197 A61K9/08 A61K47/18 

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology and is a stable antibody-containing formulation which is suitable for subcutaneous administration, comprising amino acid-aspartate or basic amino acid-glutamate and/or buffer, selected from group, comprising histidine-aspartate, histidine-glutamate buffer, tris(hydroxymethyl)aminomethane-aspartate buffer or tris(hydroxymethyl)aminomethane-glutamate buffer, wherein the antibody concentration is 50 mg/ml or more, and the antibody is an antibody that has been modified to have an isoelectric point (pI) of 5 to 8.

EFFECT: invention allows to obtain a significant stabilization effect by using an aspartic acid or glutamic acid, as a counter ion species in histidine buffer or tris(hydroxymethyl)aminomethane, specifically by using histidine-aspartate buffer or histidine-glutamate buffer, or tris(hydroxymethyl)aminomethane-aspartate or tris(hydroxymethyl)aminomethane-glutamate as a buffer.

19 cl, 24 dwg, 8 ex, 14 tbl